The uric acid disease can be caused by the buildup of uric acid in the joint. Actually, uric acid is a waste that is formed from the decomposition of purine substances that exist in the body’s cells. Under normal conditions, most uric acid is removed through the kidneys in the form of urine and a small fraction is removed through the digestive tract in the form of feces.
Uric acid disease is a condition that can cause unbearable pain symptoms, swelling, and hot feeling in the joints. Although all joints in the body can be exposed to uric acid, but the most frequently attacked is the joints of fingers, knees, ankles, and toes.
If uric acid is removed from the body much less than the amount produced, then uric acid will accumulate and form sharp crystals of micro-sodium urate that empties into the joint or around the joint tissue. When these sharp crystals enter the joint space and disrupt the soft lining of the joints, there is inflammation that feels very painful.
People affected by gout disease will usually feel the rapid development of symptoms within the first few hours. The pain can last for 3-10 days. Swelling not only occurs in the joints, but also in the area around the joints accompanied by reddening skin tone. At this stage, the patient can not move freely.
There are several factors that can trigger an increase in uric acid levels in the blood, one of which is a high purine foods we consume. Examples of such foods are animal innards (kidneys, liver, heart), seafood (shellfish, crab, anchovy, mackerel), and red meat (beef, goat, buffalo).
Beside food factor, we can also risk the buildup of uric acid in the blood if you consume sweet drinks (both artificial and natural sugar) and alcoholic beverages in excess.
The risk of uric acid disease is also high for people undergoing treatment with certain types of drugs, such as niacin, aspirin, angiotensin converting enzyme inhibitors, beta blockers, sislosporins, diuretics, and chemotherapy drugs.
Whereas if seen as a form of complication, high risk uric acid disease experienced by people who are suffering from chronic kidney disease, diabetes, hypertension, obesity, high cholesterol, osteoarthritis, psoriasis, and metabolic syndrome.
Apart from the four trigger factors above, uric acid disease is also thought to go into a group of genetic diseases derived. This means that those who have a family member with uric acid disease are at risk of experiencing the same condition. According to the study, the proportion of this risk is 20 percent.
When viewed from the sex, then women have a smaller risk of diabetes than men. The fewer number of women affected by uric acid disease than men may be linked to menopausal conditions. After women experience menopause, uric acid levels may increase and begin to experience the symptoms of uric acid.
Apart from the above factors, there are also some people who have high uric acid levels in their blood, but there is no formation of sodium crystals in the joints. In addition, among some people who have the same uric acid levels, their level of susceptibility will vary. Regarding this matter, until now there is no definitive explanation.